ฤทธิ์ยับยั้งการเจริญและการแพร่กระจายของเซลล์มะเร็งปอด A549 ของสารแอนโดรกราโฟไลด์ที่แยกจากฟ้าทะลายโจร

ชุติมา แก้วพิบูลย์

ณวงศ์ บุนนาค

(ติดต่อซ์้อฟ้าทะลายโจร โทร+ไลน์ 0809898770)

Abstract

Lung cancer has been a disease with high fatality rate due to the high metastatic rate. One of the most essential processes of metastasis is the ability of cancer cells to undergo the epithelial to mesenchymal transition (EMT) which allows cancer cells to resist the programmed cell death in a detached condition and to migrate into the surrounding organ tissue. Andrographolide has been a promising naturally derived compound for cancer therapy due to several cytotoxic effects in various cancer cells. Therefore, this study has demonstrated that andrographolide inhibits cell proliferation and metastasis process in A549 human lung cancer cells. Cytotoxicity of andrographolide on A549 and Vero cells using MTT assay showed that andrographolide decreased the viability of A549 human lung cancer cells with IC50 value at 5.51 µg/mL, whereas it performed non-cytotoxic against Vero normal cell lines. Furthermore, andrographolide decreased the migration process. As the results, andrographolide is found to be a potential compound for studying its mechanisms to further develop as cancer therapeutic drug.

https://li01.tci-thaijo.org/index.php/tstj/issue/view/16325

Author Biographies

ชุติมา แก้วพิบูลย์

สาขาวิชาชีววิทยา คณะวิทยาศาสตร์ มหาวิทยาลัยทักษิณ วิทยาเขตพัทลุง ตำบลบ้านพร้าว อำเภอป่าพะยอม จังหวัดพัทลุง 93210

ณวงศ์ บุนนาค

สาขาวิชาวิทยาศาสตร์และคณิตศาสตร์พื้นฐาน คณะวิทยาศาสตร์ มหาวิทยาลัยทักษิณ ตำบลเขารูปช้าง อำเภอเมือง จังหวัดสงขลา 90000

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https://li01.tci-thaijo.org/index.php/tstj/article/view/235655